Ergotamine tartrate
Caffeine / Ergotamine, Ergomar, Migergot (ergotamine tartrate) is a small molecule pharmaceutical. Ergotamine tartrate was first approved as Cafergot on 1982-01-01. It is used to treat cluster headache, migraine disorders, and postpartum hemorrhage in the USA.
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Commercial
Therapeutic Areas
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Ergomar
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ergomar | ANDA | 2025-02-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| migraine disorders | EFO_0003821 | D008881 | G43 |
| cluster headache | — | D003027 | G44.00 |
| postpartum hemorrhage | — | D006473 | O72 |
Agency Specific
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HCPCS
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Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | — | 3 | 1 | — | 5 |
| Headache | D006261 | — | R51 | — | — | 1 | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine without aura | D020326 | EFO_0005296 | G43.0 | 1 | — | 3 | — | — | 4 |
| Migraine with aura | D020325 | EFO_0005295 | G43.1 | 1 | — | 3 | — | — | 4 |
| Tension-type headache | D018781 | — | G44.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | — | — | — | — | 1 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibrosis | D005355 | — | — | — | — | — | — | 1 | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 1 | 1 |
| Heart valve diseases | D006349 | EFO_0009551 | I08 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ergotamine tartrate |
| INN | ergotamine |
| Description | Ergotamine is a peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10. It has a role as a non-narcotic analgesic, a vasoconstrictor agent, a serotonergic agonist, an alpha-adrenergic agonist, a mycotoxin and an oxytocic. It is a conjugate base of an ergotamine(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21.CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21.O=C(O)C(O)C(O)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 113-15-5 |
| RxCUI | 4025 |
| ChEMBL ID | CHEMBL2448612 |
| ChEBI ID | — |
| PubChem CID | 8223 |
| DrugBank | DB00696 |
| UNII ID | PR834Q503T (ChemIDplus, GSRS) |
Target
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Migergot – Horizon Therapeutics Public
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Tabular view
Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 1,060 documents
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Safety
Black-box Warning
Black-box warning for: Ergomar
Adverse Events
Top Adverse Reactions
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1,735 adverse events reported
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